Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Decomposition Reactions02:17

Synthesis and Decomposition Reactions

37.9K
Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes. 
37.9K
Cycloaddition Reactions: Overview01:16

Cycloaddition Reactions: Overview

3.3K
Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
3.3K
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation01:27

Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation

2.7K
Robinson annulation is a base-catalyzed reaction for the synthesis of 2-cyclohexenone derivatives from 1,3-dicarbonyl donors (such as cyclic diketones, β-ketoesters, or β-diketones) and α,β-unsaturated carbonyl acceptors. Named after Sir Robert Robinson, who discovered it, this reaction yields a six-membered ring with three new C–C bonds (two σ bonds and one π bond).
2.7K
Limitations of Friedel–Crafts Reactions01:26

Limitations of Friedel–Crafts Reactions

6.6K
Several restrictions limit the use of Friedel–Crafts reactions. First, the halogen in the alkyl halide must be attached to an sp3-hybridized carbon for the Friedel–Crafts reactions to occur. Vinyl or aryl halides do not react since the carbocations formed are unstable under the reaction conditions. Second, Friedel–Crafts alkylation is susceptible to carbocation rearrangement, and the major products obtained have a rearranged carbon skeleton. In contrast, the acylium ion is...
6.6K
Cycloaddition Reactions: MO Requirements for Photochemical Activation01:12

Cycloaddition Reactions: MO Requirements for Photochemical Activation

2.5K
Some cycloaddition reactions are activated by heat, while others are initiated by light. For example, a [2 + 2] cycloaddition between two ethylene molecules occurs only in the presence of light. It is photochemically allowed but thermally forbidden.
2.5K
Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

2.5K
Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Programmable Luminescent Sensing Platform via Site-Selective Modular Installation in Metal-Organic Frameworks.

Angewandte Chemie (International ed. in English)·2026
Same author

Temperature-Sensitive Carbon Capture in MOFs for Energy-Efficient Flue Gas and Biogas Purification.

ACS applied materials & interfaces·2026
Same author

Emergence of Chiral Defective Pores Through Chiral Linker Exchange in Nonchiral MOFs for Enantioselective Recognition.

Angewandte Chemie (International ed. in English)·2026
Same author

High Center-of-Mass, Multi-Legged Soft Robots Powered by Geometrically Encoded Liquid Crystal Elastomer Arc Appendages.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Methane storage using metal-dipyrazolate frameworks.

Nature materials·2026
Same author

Mitigating the Viscosity-Concentration Trade-Off in Imidazolium-Functionalized Viologens for Aqueous Organic Redox Flow Batteries.

Journal of the American Chemical Society·2026

Related Experiment Video

Updated: Dec 30, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

7.2K

Modular Total Synthesis in Reticular Chemistry.

Liang Feng1, Kun-Yu Wang1, Xiu-Liang Lv1,2

  • 1Department of Chemistry , Texas A&M University , College Station , Texas 77843-3255 , United States.

Journal of the American Chemical Society
|January 24, 2020
PubMed
Summary

This study introduces a modular synthesis strategy for creating complex hierarchical framework materials by linking metal-organic frameworks (MOFs) and covalent organic frameworks (COFs). This approach enables controlled alignment and tunability in advanced materials.

More Related Videos

Synthesis of a Water-soluble Metal–Organic Complex Array
06:40

Synthesis of a Water-soluble Metal–Organic Complex Array

Published on: October 8, 2016

11.9K
Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
07:14

Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers

Published on: May 12, 2023

3.6K

Related Experiment Videos

Last Updated: Dec 30, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

7.2K
Synthesis of a Water-soluble Metal–Organic Complex Array
06:40

Synthesis of a Water-soluble Metal–Organic Complex Array

Published on: October 8, 2016

11.9K
Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
07:14

Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers

Published on: May 12, 2023

3.6K

Area of Science:

  • Materials Science
  • Chemistry
  • Nanotechnology

Background:

  • Modularity in organic synthesis enables diverse natural product construction via varied building blocks and sequences.
  • Current modular synthesis is primarily limited to covalent-bonded molecular compounds.
  • Reticular chemistry offers a framework for assembling materials through predictable bonding interactions.

Purpose of the Study:

  • To expand the concept of modular synthesis to hierarchical framework materials.
  • To bridge metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) in a hierarchical manner.
  • To achieve controlled alignment and tunability in multicomponent framework materials.

Main Methods:

  • Development of a modular synthesis strategy for progressive assembly of building blocks.
  • Hierarchical linking of MOFs and COFs through sequence-defined reactions.
  • Utilizing coordination or covalent bond strengths to direct assembly sequences.

Main Results:

  • Successful synthesis of hierarchical COF-on-MOF structures with intricate architectures.
  • Demonstration of controlled covalent organic framework (COF) alignment within composite materials.
  • Management of tunability in spatial apportionment, composition, and functionality of framework materials.

Conclusions:

  • This work presents the first synthesis of COF@MOF composites and controlled COF alignment.
  • The generalizable modularity strategy accelerates the discovery of multicomponent framework materials.
  • This approach provides a predictable route to smart materials with enhanced tunability.