Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Silver Oxide Reduction Chemistry in an Alcohol Environment.

ACS omega·2026
Same author

<i>Trans</i>-Phosphonamidate Exchange Enables Epoxy Covalent Adaptable Networks with Intrinsic Fire Safety.

ACS applied materials & interfaces·2026
Same author

Computational engineering of the polyester hydrolase PHL7 for efficient poly(ethylene terephthalate) degradation in biocatalytic recycling processes.

Nature communications·2026
Same author

<sup>119</sup>Sn Element-Specific Phonon Density of States of BaSnO<sub>3</sub>.

Crystals·2026
Same author

Surface modification of PET Fiber: Evaluation of the synergistic effect of a thermostable engineered cutinase with DBD plasma pretreatment.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Investigating the Interfacial Structure of Potato Protein Microgels at the Air-Water Interface.

Langmuir : the ACS journal of surfaces and colloids·2025

Related Experiment Video

Updated: Dec 30, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.9K

Structurally Tunable pH-responsive Phosphine Oxide Based Gels by Facile Synthesis Strategy.

Rashid Nazir1, Dambarudhar Parida1, Anne Géraldine Guex2

  • 1Laboratory of Advanced Fibers , Empa, Swiss Federal Laboratories for Materials Science and Technology , Lerchenfeldstrasse 5 , CH-9014 St. Gallen , Switzerland.

ACS Applied Materials & Interfaces
|January 24, 2020
PubMed
Summary

This study presents a novel, catalyst-free method for synthesizing pH-responsive nanostructured gels. These tunable gels show potential for controlled drug delivery, with no observed cytotoxicity in preliminary tests.

Keywords:
Michael additionSAXSdrug releasepH-sensitive gelphosphorus

More Related Videos

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
07:20

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

4.2K
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.7K

Related Experiment Videos

Last Updated: Dec 30, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.9K
Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
07:20

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

4.2K
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.7K

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Nanostructured responsive gels are crucial for biomedical applications, particularly as drug carriers.
  • Controlling polymer configurations and nanodomain sizes is key to their function.
  • Existing synthesis methods can be complex and require post-purification steps.

Purpose of the Study:

  • To develop a facile, one-step synthesis for pH-responsive nanostructured gels.
  • To control nanoscale structural features and tune gel properties.
  • To evaluate the drug release behavior and biocompatibility of the synthesized gels.

Main Methods:

  • Catalyst-free Michael addition polymerization of trivinylphosphine oxide (TVPO) and cyclic secondary diamine monomers.
  • Nuclear Magnetic Resonance (NMR) for chemical analysis and reaction monitoring.
  • Small-Angle X-ray Scattering (SAXS) for characterizing nanostructure.
  • In vitro drug release studies using anionic dyes (acid blue 80, 90, fluorescein) at varying pH and in biological fluids.
  • In vitro cytotoxicity evaluation using human dermal fibroblasts.

Main Results:

  • A transparent, impurity-free, pH-responsive gel was synthesized in one step without catalysts or post-purification.
  • Nanodomain size within the gel network was tunable by varying amine monomers and solvents.
  • pH-dependent drug release was observed, with higher release at alkaline pH (pH 10) for certain dyes.
  • Ionic interactions with metal ions in PBS and SBF positively influenced drug release.
  • Minimal drug release (<1%) was observed for acid blue 90 due to its reactivity with the gel matrix.
  • The hydrogels exhibited no cytotoxic effects on human dermal fibroblasts.

Conclusions:

  • The developed catalyst-free method offers a straightforward route to tunable, pH-responsive nanostructured gels.
  • The gels demonstrate potential as smart drug delivery systems with controlled release profiles.
  • The biocompatibility and tunable nanostructure position these materials for further biomedical research and development.