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HISTOLOGIC FINDINGS IN VITREORETINAL LYMPHOMA: Learning From Enucleation Specimens
Sam T Albadri1, Jose S Pulido2, William R Macon1
1Departments of Laboratory Medicine and Pathology; and.
Retina (Philadelphia, Pa.)
|January 24, 2020
Summary
Enucleation for intraocular lymphoma is rare. This study details clinical and histologic findings in four cases, highlighting varied ocular tissue involvement patterns in primary and secondary lymphomas.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Intraocular lymphoma is a rare malignancy that can present with diverse clinical and histologic features.
- Enucleation, the removal of the eye, is an uncommon surgical intervention for intraocular lymphoma.
Observation:
- This retrospective study reviewed four cases of enucleation specimens over 22 years diagnosed with intraocular lymphoma.
- Patients included three women and one man, aged 60-80 years, presenting with varied symptoms and histories.
Findings:
- Two patients had primary vitreoretinal large B-cell lymphomas, initially treated for refractory uveitis, with specimens showing atypical B-lymphocyte infiltrates.
- Two patients had secondary intraocular lymphoma: one with chronic lymphocytic leukemia experiencing Richter transformation, and another with diffuse large B-cell lymphoma causing panuveitis.
Implications:
- This series illustrates the unusual indications for enucleation due to intraocular lymphoma.
- Understanding the distinct patterns of ocular involvement in primary versus secondary intraocular lymphomas is crucial for diagnosis and management.
