Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged Adults
Lucas Jurado-Fasoli1, Manuel J Castillo1, Francisco J Amaro-Gahete1
1Department of Physiology, Faculty of Medicine, University of Granada, 18016 Granada, Spain.
Background:
Soluble Klotho (S-Klotho) is an aging suppressor with a close link with inflammation. However, it is still unknown whether the dietary inflammatory potential is associated with S-Klotho plasma level. We aimed to investigate the association of the Dietary Inflammatory Index (DII) with S-Klotho plasma levels in middle-aged sedentary adults.
Methods:
73 middle-aged sedentary adults (40-65 years old) participated in the present study. DII was determined from 28 dietary items obtained by 24 h recalls and food frequency questionnaires. The S-Klotho plasma levels were measured using a solid-phase sandwich enzyme-linked immunosorbent assay.
Results:
a weak positive association was observed between DII and S-Klotho plasma levels (β = 52.223, R2 = 0.057, p = 0.043), which disappeared after controlling for body mass index (p = 0.057).
Conclusions:
A pro-inflammatory dietary pattern measured with the DII was slightly and positively associated with S-Klotho plasma levels in middle-aged sedentary adults.
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