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A Naphthalenediimide-Based Fluorescent Sensor for Detecting the pH within the Rough Endoplasmic Reticulum of Living
Namdev V Ghule1, Rajesh S Bhosale2, Kiran Kharat3
1Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad, Telangana 500007 (India).
Abstract:
An amino-core-substituted naphthalenediimide (NDI) derivative has been synthesized in good yield in two steps. The NDI bearing a diamine moiety undergoes a reversible protonation-deprotonation process, which results in intensity changes in the absorption and emission spectra. This derivative exhibits good photostability, good selectivity, high sensitivity, and is employed to exhibit the pH within the rough endoplasmic reticulum of living cells.
