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Presynaptically Silent Synapses Studied with Light Microscopy
Published on: January 4, 2010
SYNPLA, a method to identify synapses displaying plasticity after learning
Kim Dore1, Yvonne Pao1, Jose Soria Lopez1
1Center for Neural Circuits and Behavior, Department of Neuroscience and Section for Neurobiology, Division of Biology, University of California San Diego, La Jolla, CA 92093.
Abstract:
Which neural circuits undergo synaptic changes when an animal learns? Although it is widely accepted that changes in synaptic strength underlie many forms of learning and memory, it remains challenging to connect changes in synaptic strength at specific neural pathways to specific behaviors and memories. Here we introduce SYNPLA (synaptic proximity ligation assay), a synapse-specific, high-throughput, and potentially brain-wide method capable of detecting circuit-specific learning-induced synaptic plasticity.
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