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Related Concept Videos

Drug Product Stability01:16

Drug Product Stability

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The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...
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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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Starch granule stabilized Pickering emulsions: an 8-year stability study.

Ali Marefati1, Marilyn Rayner1

  • 1Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden.

Journal of the Science of Food and Agriculture
|January 25, 2020
PubMed
Summary

Quinoa starch Pickering emulsions demonstrate exceptional eight-year stability without coalescence. Higher starch concentrations yielded smaller droplet sizes, indicating potential for long-term food formulations.

Keywords:
OSA modifiedPickering emulsionsquinoastarch granulesstorage stability

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Area of Science:

  • Colloid and Surface Science
  • Food Science and Technology
  • Materials Science

Background:

  • Pickering emulsions offer superior stability against coalescence compared to conventional emulsions.
  • This study investigates the long-term (eight-year) stability of oil-in-water Pickering emulsions.
  • Emulsions were stabilized using quinoa starch granules modified with octenyl succinic anhydride (OSA).

Purpose of the Study:

  • To evaluate the eight-year storage stability of OSA-modified quinoa starch Pickering emulsions.
  • To determine the effect of starch concentration on emulsion properties and stability.
  • To assess the suitability of these emulsions for applications requiring prolonged storage.

Main Methods:

  • Oil-in-water Pickering emulsions were prepared using a high-pressure homogenizer.
  • Two starch concentrations (200 and 600 mg/mL oil) were tested at an oil fraction of 0.1.
  • Emulsions were stored at 6°C and analyzed for particle size over eight years; microscopy was used at the end.

Main Results:

  • The starch-stabilized Pickering emulsions exhibited remarkable stability over eight years, with no signs of coalescence.
  • Increased starch concentration led to a reduction in droplet size.
  • Droplet sizes decreased over time due to the dissociation of aggregated droplet networks, releasing entrapped starch.

Conclusions:

  • Pickering emulsions stabilized by OSA-modified quinoa starch granules demonstrate excellent long-term stability.
  • These emulsions are suitable for practical applications requiring highly stable formulations.
  • The findings support the use of modified quinoa starch as an effective stabilizer for emulsions.