Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Schizophrenia01:17

Schizophrenia

629
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
629
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

746
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
746
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

1.7K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.7K
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

409
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
409
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

432
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
432
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

457
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
457

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ARCH × Φ: Sterols and the evolution of gated biological execution.

Bio Systems·2026
Same author

Molybdenum-Catalyzed One-Step Synthesis of Tetrahydroquinolines.

Precision chemistry·2026
Same author

A multiplicative behavioral model of DNA replication initiation in cells.

Open life sciences·2026
Same author

Sex change in clownfish as an ARCH-governed biological decision.

Hormones and behavior·2026
Same author

Threshold decision-making in the Venus flytrap.

Plant science : an international journal of experimental plant biology·2026
Same author

The ARCH model: a neuroevolutionary framework for behavioral execution.

Frontiers in psychiatry·2025
Same journal

Anabolic Androgenic Steroids: Emerging Use Disorder, Mechanisms of Action, and Clinical Considerations for Pharmacotherapy.

Focus (American Psychiatric Publishing)·2026
Same journal

Major Depression and Antidepressant Treatment: Impact on Pregnancy and Neonatal Outcomes.

Focus (American Psychiatric Publishing)·2026
Same journal

Violence Risk Factors in Psychiatric Populations.

Focus (American Psychiatric Publishing)·2026
Same journal

Contextualizing Violence Risk Associated With Hallucinogens.

Focus (American Psychiatric Publishing)·2026
Same journal

Ethical and Legal Aspects of Forensic Psychiatry.

Focus (American Psychiatric Publishing)·2026
Same journal

From Fear to Framework: Toward Understanding of Violence and Mental Illness.

Focus (American Psychiatric Publishing)·2026
See all related articles

Related Experiment Video

Updated: Dec 30, 2025

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

18.9K

Schizophrenia: An Overview.

Tahir Rahman1, John Lauriello1

  • 1Dr. Rahman is assistant professor of Clinical Psychiatry, University of Missouri-Columbia. Dr. Lauriello is professor and chairman of the Department of Psychiatry and a Robert J. Douglas, M.D., and Betty Douglas Distinguished Faculty Scholar in Psychiatry, University of Missouri-Columbia.

Focus (American Psychiatric Publishing)
|January 25, 2020
PubMed
Summary
This summary is machine-generated.

Schizophrenia research advances understanding of its causes through genetics, neuroimaging, and immune function studies. These findings pave the way for novel treatment strategies for this chronic mental illness.

More Related Videos

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.3K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

7.4K

Related Experiment Videos

Last Updated: Dec 30, 2025

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

18.9K
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.3K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

7.4K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Schizophrenia is a chronic mental illness characterized by positive, negative, and cognitive symptoms.
  • Diagnostic criteria in DSM-5 saw minimal changes.
  • Etiology remains elusive despite ongoing research.

Purpose of the Study:

  • To provide a comprehensive overview of current literature on schizophrenia.
  • To highlight recent advancements in understanding the disease's underlying mechanisms.

Main Methods:

  • Literature review of current research.
  • Synthesis of findings from genetics, neuroimaging, and immunology.

Main Results:

  • Genomewide association studies and twin studies reveal genetic links.
  • Neuroimaging shows alterations in brain structure (e.g., ventricular size).
  • Immune factors like complement component 4 and MHC markers are implicated.

Conclusions:

  • Advances in genetics, neuroimaging, and immunology are crucial for understanding schizophrenia.
  • Identifying risk factors like obstetrical complications, cannabis use, and trauma is important.
  • Future novel treatment strategies are anticipated based on elucidated disease mechanisms.