Molybdenum-Catalyzed One-Step Synthesis of Tetrahydroquinolines

Through an earth-abundant molybdenum-catalyzed, borrowing hydrogen coupling reaction, a simple and efficient synthesis of tetrahydroquinolines from (2-amino aryl) methanol and α-branched alcohols has been reported. The current methodology proceeds via an atom-efficient and step-economic pathway, along with no need for further reducing agent, broad substrate scope, and operational simplicity, providing a practical and important way for the smooth synthesis of these types of biologically relevant products.