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Updated: Dec 30, 2025

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
Therapeutic Uses of Seizures in Neuropsychiatry
M Justin Coffey1, Joseph J Cooper1
1Center for Brain Stimulation, The Menninger Clinic (Coffey), Department of Psychiatry & Behavioral Sciences, Baylor College of Medicine (Coffey), and Department of Clinical Psychiatry, University of Illinois at Chicago (Cooper).
Abstract:
Although seizures typically indicate a state of brain dysfunction, there are circumstances in which the biological effects of a seizure may exert therapeutic benefits. The standard technique for inducing controlled therapeutic seizures in humans is electroconvulsive therapy (ECT), a treatment that involves the application of an electrical stimulus to the scalp of a patient under general anesthesia and muscle relaxation. This review discusses the contemporary use of ECT for treating certain mental and neurologic disorders and previews two experimental forms of seizure therapy that are related to ECT and may hold promise for the future: focal electrically administered seizure therapy and magnetic seizure therapy.
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