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Updated: Dec 30, 2025
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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
Published on: April 11, 2016
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Enabling Precision Oncology Through Precision Diagnostics.
Noah A Brown1, Kojo S J Elenitoba-Johnson2
1Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA;
Annual Review of Pathology
|January 25, 2020
Summary
Genomic testing, using next-generation sequencing, allows for personalized cancer treatment. Challenges remain in integrating this technology into routine clinical practice for precision oncology.
Area of Science:
- Oncology
- Genomics
- Bioinformatics
Background:
- Genomic testing tailors cancer management to individual molecular profiles.
- Next-generation sequencing (NGS) has transformed cancer genomics, enabling rapid, cost-effective genome analysis.
Purpose of the Study:
- To highlight the role of genomic testing in precision oncology.
- To identify challenges in translating NGS from research to clinical practice.
Main Methods:
- Review of genomic testing applications in cancer care.
- Discussion of challenges in clinical implementation of NGS.
Main Results:
- Genomic sequencing aids in cancer detection, classification, prognosis, and targeted therapy.
- Precision oncology is emerging as a key paradigm for cancer treatment.
Conclusions:
- Efficient clinical integration of NGS requires addressing data management, interpretation, and interdisciplinary coordination.
- Overcoming implementation hurdles is crucial for realizing the full potential of precision oncology.
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