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Diffuse Hepatosplenic 99mTc-Pyrophosphate Activity Caused by Amyloidosis
Jingyun Ren1, Chao Ren1, Li Huo1
1From the Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine.
Tc-pyrophosphate scans can reveal liver and spleen abnormalities, indicating light chain amyloidosis. This diagnostic approach aids in identifying infiltrative myocardiopathy when cardiac imaging is inconclusive.
Area of Science:
- Nuclear medicine
- Cardiology
- Hepatology
Background:
- Echocardiography suggested infiltrative myocardiopathy in a 46-year-old man.
- Technetium-pyrophosphate (Tc-PYP) scintigraphy was employed for further cardiac evaluation.
Observation:
- Cardiac Tc-PYP scan showed no abnormal uptake, ruling out significant cardiac involvement.
- Diffuse abnormal radiotracer activity was observed in the liver and spleen.
Findings:
- Hepatic biopsy confirmed the presence of amyloidosis, specifically light chain type.
- The scan findings suggested systemic amyloid deposition rather than primary cardiac disease.
Implications:
- Tc-PYP scintigraphy can be valuable in diagnosing systemic amyloidosis, even when cardiac uptake is negative.
- This case highlights the importance of considering non-cardiac findings on Tc-PYP scans for diagnosing systemic diseases like amyloidosis.
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