Related Experiment Video
Updated: Dec 30, 2025
07:00
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
6.2K
Prostate-Specific Membrane Antigen Expression in Primary Juvenile Nasal Angiofibroma-A Pilot Study
Pirabu Sakthivel1, Alok Thakar1, Arun Prashanth2
1From the Department of Otorhinolaryngology & Head and Neck Surgery.
Clinical Nuclear Medicine
|January 25, 2020
Summary
Prostate-specific membrane antigen (PSMA) is highly expressed in juvenile nasal angiofibroma (JNA), enabling new imaging and treatment possibilities. PSMA PET/CT scans revealed significant uptake in JNA tumors, aiding in staging and characterization.
Area of Science:
- Oncology
- Radiology
- Molecular Imaging
Background:
- Prostate-specific membrane antigen (PSMA) is a validated target in prostate cancer.
- PSMA is also expressed in tumor-associated neovasculature.
- Juvenile nasal angiofibroma (JNA) is a highly vascular tumor.
Purpose of the Study:
- To assess PSMA expression in primary JNA using PSMA PET/CT.
- To evaluate the potential of PSMA imaging for JNA staging and characterization.
Main Methods:
- Prospective study of 25 primary JNA patients.
- PSMA PET/CT scans performed after IV injection of Ga-PSMA-HBED-CC.
- Analysis of PSMA uptake intensity and pattern.
Main Results:
- 100% of JNA cases showed PSMA expression.
- Median tumor-to-background SUVmax ratio was 4.57.
- Advanced stage tumors had significantly greater PSMA uptake (P=0.011).
Conclusions:
- PSMA PET/CT is a valuable tool for JNA radiological staging and molecular characterization.
- PSMA imaging may aid in identifying residual/recurrent JNA.
- Potential for radioligand therapy in JNA is suggested.
