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Long non-coding RNA TP73-AS1 in cancers

Chao-Yang Gong1, Rong Tang2, Kai-Xing Liu1

  • 1The Second Clinical Medical College of Lanzhou University, 82 Cuiying Men, Lanzhou 730030, PR China; Orthopaedics Key Laboratory of Gansu Province, Lanzhou 730000, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 25, 2020
PubMed

Insights

Long non-coding RNAs (lncRNAs) are crucial in cancer. TP73-AS1, a specific lncRNA, acts as a cancer regulator, impacting progression and offering potential as a biomarker and therapeutic target.

Area of Science:

  • Molecular Biology
  • Oncology
  • RNA Biology

Background:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in human cancers, acting as oncogenes or tumor suppressors.
  • Tumor protein P73 antisense RNA 1 (TP73-AS1) was initially identified as downregulated in oligodendroglioma.
  • TP73-AS1 has since emerged as a significant regulator in various malignancies.

Purpose of the Study:

  • To review the biological functions of TP73-AS1 in tumorigenesis.
  • To elucidate the mechanisms by which TP73-AS1 influences cancer progression.
  • To discuss the potential clinical implications of TP73-AS1 as a biomarker and therapeutic target.

Main Methods:

  • Literature review of studies on TP73-AS1.
  • Analysis of TP73-AS1 expression and its correlation with clinicopathological features.
  • Investigation of TP73-AS1's role in cell proliferation, apoptosis, invasion, and metastasis.

Main Results:

  • TP73-AS1 is highly expressed in many cancers and linked to adverse clinicopathological features.
  • TP73-AS1 regulates key cancer processes including proliferation, anti-apoptosis, invasion, and metastasis.
  • Dysregulation of TP73-AS1 is implicated in the occurrence and progression of human cancers.

Conclusions:

  • TP73-AS1 plays a critical role in cancer development and progression.
  • TP73-AS1 exhibits potential as a promising biomarker for cancer diagnosis and prognosis.
  • Targeting TP73-AS1 represents a potential therapeutic strategy for various cancers.
Keywords:
CancersMechanismsTP73-AS1lncRNA

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