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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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piRNA - Piwi-interacting RNAs02:57

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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Related Experiment Video

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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Long non-coding RNA TP73-AS1 in cancers.

Chao-Yang Gong1, Rong Tang2, Kai-Xing Liu1

  • 1The Second Clinical Medical College of Lanzhou University, 82 Cuiying Men, Lanzhou 730030, PR China; Orthopaedics Key Laboratory of Gansu Province, Lanzhou 730000, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 25, 2020
PubMed
Summary

Long non-coding RNAs (lncRNAs) are crucial in cancer. TP73-AS1, a specific lncRNA, acts as a cancer regulator, impacting progression and offering potential as a biomarker and therapeutic target.

Keywords:
CancersMechanismsTP73-AS1lncRNA

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Area of Science:

  • Molecular Biology
  • Oncology
  • RNA Biology

Background:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in human cancers, acting as oncogenes or tumor suppressors.
  • Tumor protein P73 antisense RNA 1 (TP73-AS1) was initially identified as downregulated in oligodendroglioma.
  • TP73-AS1 has since emerged as a significant regulator in various malignancies.

Purpose of the Study:

  • To review the biological functions of TP73-AS1 in tumorigenesis.
  • To elucidate the mechanisms by which TP73-AS1 influences cancer progression.
  • To discuss the potential clinical implications of TP73-AS1 as a biomarker and therapeutic target.

Main Methods:

  • Literature review of studies on TP73-AS1.
  • Analysis of TP73-AS1 expression and its correlation with clinicopathological features.
  • Investigation of TP73-AS1's role in cell proliferation, apoptosis, invasion, and metastasis.

Main Results:

  • TP73-AS1 is highly expressed in many cancers and linked to adverse clinicopathological features.
  • TP73-AS1 regulates key cancer processes including proliferation, anti-apoptosis, invasion, and metastasis.
  • Dysregulation of TP73-AS1 is implicated in the occurrence and progression of human cancers.

Conclusions:

  • TP73-AS1 plays a critical role in cancer development and progression.
  • TP73-AS1 exhibits potential as a promising biomarker for cancer diagnosis and prognosis.
  • Targeting TP73-AS1 represents a potential therapeutic strategy for various cancers.