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Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens
Mioko Kawaguchi1, Masayuki Satake2, Bo-Tao Zhang1
1Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan.
Abstract:
A new aplysiatoxin derivative, neo-aplysiatoxin A (1), along with seven known compounds, neo-debromoaplysiatoxin A (2), dolastatin 3 (3), lyngbic acid (4), malyngamide M (5), hermitamide A (6), (-)-loliolide (7), and (+)-epiloliolide (8), was isolated from the Okinawan cyanobacterium Moorea producens. Their structures were elucidated on the basis of spectroscopic data, including high-resolution mass spectrometry and nuclear magnetic resonance. The compounds were evaluated for cytotoxic and diatom growth inhibition activities.
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