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Active MMP-8 (aMMP-8) as a Grading and Staging Biomarker in the Periodontitis Classification
Timo Sorsa1,2, Saeed Alassiri1, Andreas Grigoriadis3,4
1Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, P.O. Box 63 (Haartmaninkatu 8) FI-00014, 00100 Helsinki, Finland.
Diagnostics (Basel, Switzerland)
|January 26, 2020
Summary
Active matrix metalloproteinase-8 (aMMP-8) is a valuable biomarker for diagnosing periodontitis stages and grades. This rapid point-of-care test offers a reliable, chairside tool for identifying periodontal disease and breakdown.
Area of Science:
- Periodontology
- Biomarker Discovery
- Diagnostic Tools
Background:
- The 2018 periodontitis classification system requires robust diagnostic tools.
- Active matrix metalloproteinase-8 (aMMP-8) is a potential biomarker for periodontal tissue breakdown.
- Current diagnostic methods may be confounded by patient oral hygiene practices.
Purpose of the Study:
- To evaluate the utility of active matrix metalloproteinase-8 (aMMP-8) as a biomarker within the 2018 periodontitis classification system.
- To assess the correlation of aMMP-8 levels with periodontitis severity and traditional clinical parameters.
Main Methods:
- A cohort of 150 Greek adults underwent aMMP-8 point-of-care mouthrinse testing.
- Full-mouth clinical examinations were performed to assess periodontal status.
- Statistical analyses, including Kruskal-Wallis and Spearman's rho, were used to compare aMMP-8 levels and clinical parameters.
Main Results:
- Significantly lower aMMP-8 levels were observed in healthy patients compared to those with severe periodontitis (p < 0.01).
- aMMP-8 levels showed a weaker correlation with plaque than bleeding on probing (BOP) (Spearman's rho = 0.269 vs. 0.586).
- aMMP-8 proved more robust to oral hygiene confounding factors than BOP.
Conclusions:
- The aMMP-8 point-of-care mouthrinse test is a beneficial adjunctive diagnostic tool for periodontitis.
- It can rapidly identify periodontal disease stages, grades, and breakdown chairside.
- Integrating aMMP-8 into the new classification system enhances diagnostic accuracy and clinical utility.
