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Updated: Apr 10, 2026
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Proteomic Characterization of Grade II Furcation Defects: A Discovery-Phase Study
Georgios S Chatzopoulos1, Dimitra Sakellari1, Eleftherios G Kaklamanos1
1Department of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Abstract:
This study analyzed the gingival crevicular fluid (GCF) proteome of 35 patients with Grade II furcation defects using the Olink Reveal platform. Comparison with non-periodontitis sites identified 227 differentially expressed proteins. A machine-learning pipeline prioritized a 34-protein signature (including GLIPR1, MME, and IRAG2) that accurately differentiated furcation defects from health (AUC = 0.887), reflecting a distinct profile of severe inflammation and neutrophil activation.
