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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Epicardial adipose tissue: A cardiovascular risk marker to evaluate in chronic kidney disease

Luis D'Marco1, Marie Cortez2, María Salazar2

  • 1Hospital Clínico Universitario, INCLIVA, Nephrology department, Valencia , España.

Clinica E Investigacion En Arteriosclerosis : Publicacion Oficial De La Sociedad Espanola De Arteriosclerosis
|January 26, 2020
PubMed

Insights

Chronic kidney disease (CKD) is inflammatory and linked to heart risks. Epicardial adipose tissue may worsen cardiovascular issues in CKD patients, warranting further investigation.

Area of Science:

  • Nephrology
  • Cardiology
  • Metabolic Disorders

Background:

  • Chronic kidney disease (CKD) is an inflammatory condition associated with cardiovascular risk factors.
  • Coronary artery disease (CAD) is a primary complication of CKD, often linked to uremic and metabolic disturbances.
  • Epicardial adipose tissue (EAT) is emerging as a cardiovascular risk factor in the general population.

Purpose of the Study:

  • To explore the role of epicardial adipose tissue (EAT) as a cardiovascular risk factor in patients with chronic kidney disease (CKD).
  • To investigate the potential link between EAT deposition and adverse cardiovascular outcomes in renal patients.

Main Methods:

  • This study reviews current clinical evidence regarding EAT and cardiovascular risk.
  • It highlights the local pro-atherogenic mechanisms of EAT impacting coronary vessels.
  • The abstract notes the limited evaluation of EAT in the renal patient population.

Main Results:

  • Epicardial adipose tissue (EAT) deposition is identified as a potential contributor to cardiovascular risk.
  • EAT may promote atherosclerosis through local mediation of pro-atherogenic substances, causing endothelial damage.
  • The specific association between increased EAT and cardiovascular morbidity/mortality in CKD patients remains under-evaluated.

Conclusions:

  • Epicardial adipose tissue (EAT) warrants consideration as an additional cardiovascular risk factor in chronic kidney disease (CKD) patients.
  • Further research is crucial to precisely determine the impact of EAT on cardiovascular outcomes in this high-risk group.
  • Understanding EAT's role could refine cardiovascular risk assessment and management strategies for CKD patients.

Keywords:
Calcificaciones vascularesCardiovascular riskChronic kidney diseaseEnfermedad renal crónicaEpicardial adipose tissueRiesgo cardiovascularTejido adiposo epicárdicoVascular calcification

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