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Phaeodactylum tricornutum: A Diatom Cell Factory
Thomas Butler1, Rahul Vijay Kapoore2, Seetharaman Vaidyanathan1
1Department of Chemical and Biological Engineering, The University of Sheffield, Sheffield, S1 3JD, UK.
Abstract:
A switch from a petroleum-based to a biobased economy requires the capacity to produce both high-value low-volume and low-value high-volume products. Recent evidence supports the development of microalgae-based microbial cell factories with the objective of establishing environmentally sustainable manufacturing solutions. Diatoms display rich diversity and potential in this regard. We focus on Phaeodactylum tricornutum, a pennate diatom that is commonly found in marine ecosystems, and discuss recent trends in developing the diatom chassis for the production of a suite of natural and genetically engineered products. Both upstream and downstream developments are reviewed for the commercial development of P. tricornutum as a cell factory for a spectrum of marketable products.
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