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Area of Science:

  • Critical care medicine
  • Neuroscience
  • Animal models of disease

Background:

  • Reliable scoring systems are crucial for assessing critical illness severity.
  • The Sequential Organ Failure Assessment (SOFA) score is used for sepsis patients, but animal model limitations exist.
  • Sickness behavior is a key indicator of illness severity.

Purpose of the Study:

  • To develop and validate a Sickness Behavior Score (SBS) for assessing sepsis severity and mortality in an animal model.
  • To correlate SBS with established sepsis severity markers and cognitive function.

Main Methods:

  • A Sickness Behavior Score (SBS) was developed using six indicators: temperature, water/sucrose preference, liquid intake, food intake, body weight, and movement.
  • Male Wistar rats underwent cecal ligation and puncture (CLP) or sham surgery.
  • Physiological markers (oxidative stress, IL-6, corticosterone, adrenal weight), BDNF, and cognitive tests were assessed.

Main Results:

  • Septic rats exhibited significantly higher SBS compared to sham controls.
  • SBS correlated with acute and chronic sepsis severity markers, including oxidative stress and IL-6.
  • SBS was negatively correlated with cognitive test performance.

Conclusions:

  • The Sickness Behavior Score (SBS) is a reliable tool for predicting sepsis severity and mortality in experimental settings.
  • SBS provides a global assessment of sickness behavior, offering advantages over evaluating individual parameters.
  • This score system can serve as an alternative to traditional scoring methods in animal research.