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Plasma sestrin2 concentrations and carotid atherosclerosis
Yoshimi Kishimoto1, Emi Saita1, Reiko Ohmori2
1Endowed Research Department "Food for Health", Ochanomizu University, Tokyo, Japan.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 27, 2020
Summary
Plasma sestrin2 levels are elevated in individuals with carotid plaque, correlating with plaque severity. Higher sestrin2 may indicate a protective response against atherosclerosis progression.
Area of Science:
- Biochemistry
- Cardiovascular Research
- Oxidative Stress Biology
Background:
- Sestrin2 is a protein induced by stress, known for its antioxidant and cytoprotective functions.
- Its role in carotid atherosclerosis, particularly blood concentrations, remains largely uninvestigated.
Purpose of the Study:
- To determine plasma sestrin2 concentrations in individuals with carotid atherosclerosis.
- To assess the relationship between sestrin2 levels and the severity of carotid plaque.
Main Methods:
- Plasma sestrin2 levels were measured in 152 subjects undergoing carotid ultrasonography.
- Carotid plaque severity was quantified using a plaque score system.
Main Results:
- Individuals with carotid plaque (n=63) exhibited higher plasma sestrin2 concentrations than those without plaque (n=89).
- A significant positive correlation was observed between plasma sestrin2 levels and carotid plaque score.
- Multivariate analysis identified sestrin2 concentration as an independent predictor of severe plaque (score ≥2), with an odds ratio of 5.70.
Conclusions:
- Elevated plasma sestrin2 concentrations are associated with the presence and severity of carotid atherosclerosis.
- High sestrin2 levels in patients with carotid plaque may represent an endogenous protective mechanism against disease progression.
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