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Incretins and microRNAs: Interactions and physiological relevance

Shabnam Radbakhsh1, Thozhukat Sathyapalan2, Maciej Banach3

  • 1Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.

Pharmacological Research
|January 27, 2020
PubMed

Insights

MicroRNAs (miRNAs) influence incretin hormones like GLP-1 and GIP, impacting glucose control. This review explores how miRNAs interact with incretins and DPP-4 inhibitors, relevant to type 2 diabetes.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small regulatory RNAs affecting gene expression.
  • Incretin hormones (GLP-1, GLP-2, GIP) are vital for glucose homeostasis and beta-cell function.
  • Glucagon-like peptide-1 receptor agonists (GLP1RA) and DPP-4 inhibitors are used in type 2 diabetes management.

Purpose of the Study:

  • To review the interactions between miRNAs and incretin hormones.
  • To elucidate the relevance of these interactions in physiological processes and diseases, particularly type 2 diabetes.

Main Methods:

  • Literature review of studies investigating miRNA and incretin hormone interactions.
  • Analysis of how GLP1RA and DPP-4 inhibitors affect miRNA expression.
  • Synthesis of current knowledge on the physiological and pathological implications.

Main Results:

  • miRNAs can modulate the expression of incretin hormones and their receptors.
  • GLP1RA and DPP-4 inhibitors can alter miRNA expression profiles.
  • These interactions suggest a complex regulatory network influencing glucose metabolism.

Conclusions:

  • miRNA-incretin axis represents a significant area for understanding glucose homeostasis.
  • Targeting this axis may offer novel therapeutic strategies for type 2 diabetes.
  • Further research is needed to fully delineate these complex molecular interactions.
Keywords:
DPP-4 inhibitorGLP1-RIncretinIncretin receptor agonistmiRNAs

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