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Relationships between verapamil plasma concentrations and its antihypertensive action
A Gonzalez-Gomez1, M Cires Pujols, F Gamio Capestany
1Psychiatric Hospital of Havana, Cuba.
International Journal of Clinical Pharmacology, Therapy, and Toxicology
|September 1, 1988
Summary
Verapamil effectively lowers blood pressure in hypertensive patients, both alone and with oxprenolol. This calcium channel blocker shows promise for essential hypertension treatment with manageable side effects.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Essential hypertension is a prevalent cardiovascular condition requiring effective management.
- Verapamil, a calcium channel blocker, is used for cardiovascular conditions.
Purpose of the Study:
- To evaluate the efficacy of verapamil in hypertensive outpatients.
- To assess verapamil's effects as monotherapy and in combination with oxprenolol.
- To analyze the relationship between verapamil plasma concentrations and its physiological effects.
Main Methods:
- Study included 27 hypertensive outpatients.
- Evaluated verapamil after single oral dose and short-term treatment.
- Assessed combination therapy with oxprenolol.
- Monitored blood pressure, PR interval, QT interval, and systolic time intervals.
Main Results:
- Significant blood pressure reduction observed with verapamil monotherapy and combined treatment (p < 0.01).
- PR interval prolongation occurred with verapamil acute and short-term use.
- QT interval prolonged only with verapamil monotherapy.
- Correlations found between verapamil levels and blood pressure/PR changes.
- Two patients experienced atrioventricular conduction disturbances, with no further complications.
Conclusions:
- Verapamil monotherapy demonstrates efficacy in reducing blood pressure in hypertensive patients.
- Combination therapy with oxprenolol also effectively lowers blood pressure.
- Verapamil is a potential therapeutic option for essential hypertension management.