Related Experiment Videos
Potential role of PFOB in diagnostic imaging
1Department of Radiology, University of California, San Diego Medical Center 92103.
Investigative Radiology
|September 1, 1988
Summary
Perfluoroocytlbromide (PFOB) is a versatile medical compound used in diagnostic imaging. Its unique properties allow for use across multiple imaging modalities with low toxicity, showing significant potential in clinical trials.
Area of Science:
- Medical Imaging
- Biomedical Engineering
- Materials Science
Background:
- Perfluorochemicals (PFCs) offer diverse industrial and medical applications.
- Medical uses include oxygen transport and diagnostic imaging.
- PFCs are unique ultrasound contrast agents that alter tissue echogenicity.
Purpose of the Study:
- To evaluate perfluoroocytlbromide (PFOB) as a novel contrast agent.
- To highlight PFOB's unique properties for various imaging modalities.
- To assess PFOB's potential impact on diagnostic applications.
Main Methods:
- Utilizing PFOB's bromine atom for computed tomography visibility.
- Leveraging fluorine content for fluorine MR imaging.
- Employing PFOB as a signal void in hydrogen imaging.
Main Results:
- PFOB is the only PFC visible by computed tomography due to its bromine atom.
- PFOB enables fluorine MR imaging and serves as a signal void for hydrogen imaging.
- All applications are currently in clinical trials in the US and Europe.
Conclusions:
- PFOB demonstrates low or insignificant toxicity.
- PFOB offers universality across multiple imaging modalities.
- PFOB holds significant potential for advancing diagnostic applications.