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Related Experiment Videos

On internodal length.

J M Jacobs1

  • 1Department of Neuropathology, National Hospital, London.

Journal of Anatomy
|April 1, 1988
PubMed
Summary
This summary is machine-generated.

This study on rat tibial and human sural nerves reveals that internodal length increases with age and fiber diameter. Contrary to popular belief, longer internodes are not solely due to later myelination but also influenced by limb bone growth.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Histology

Background:

  • Nerve development involves changes in internodal length and myelination.
  • Understanding these changes is crucial for comprehending nerve function and aging.

Purpose of the Study:

  • To investigate age-related changes in internodal lengths of rat tibial nerves and human sural nerves.
  • To examine the relationship between internodal length, fiber diameter, and age.
  • To evaluate the influence of limb bone growth on nerve internode length.

Main Methods:

  • Analysis of myelinated fiber counts in rat tibial and human sural nerves.
  • Regression analysis of internodal length against fiber diameter at different developmental stages.
  • Correlation of rat tibial nerve internodal length with limb bone growth.

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Main Results:

  • Maximum myelinated fiber numbers are achieved early in development.
  • The relationship between internodal length and fiber diameter becomes steeper with age.
  • Internodal length in rat tibial nerves correlates with limb bone growth.
  • Larger fibers experience prolonged limb growth, resulting in longer internodes.

Conclusions:

  • Age-related changes in internodal length are significant in peripheral nerves.
  • Limb bone growth plays a key role in determining maximum internodal length, particularly for larger fibers.
  • The study challenges the notion that short internodes are solely a result of delayed myelination in smaller fibers.