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Erythromycin A 11,12-methylene acetal
E Hunt1, D J Knowles, C Shillingford
1Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Betchworth, Surrey, UK.
The Journal of Antibiotics
|November 1, 1988
Abstract:
Erythromycin A 11,12-methylene acetal (5) and the corresponding 9-methoxime, 9-dihydro, and 8-hydroxy derivatives have been prepared and their antibacterial activities compared with those of erythromycin A and its 11,12-cyclic carbonate. The simple methylene acetal 5 showed excellent activity against Gram-positive organisms in vitro.