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Age-Associated B Cells.

Michael P Cancro1

  • 1Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

Annual Review of Immunology
|January 28, 2020
PubMed
Summary
This summary is machine-generated.

Age-associated B cells are key immune cells involved in aging and disease. Understanding these cells offers potential therapeutic targets for immune health and age-related conditions.

Keywords:
B lymphocytesagingautoimmunitymemory B cells

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Area of Science:

  • Immunology
  • Cell Biology
  • Aging Research

Background:

  • Age-associated B cells (ABCs) are increasingly studied for their unique phenotype and function.
  • These cells are antigen-experienced memory B cells crucial for pathogen clearance.
  • ABCs are linked to immunosenescence and elevated in autoimmune diseases.

Purpose of the Study:

  • To explore the origins, functions, and physiology of age-associated B cells.
  • To highlight the role of ABCs in immunological health, disease, and aging.
  • To identify ABCs as potential translational targets.

Main Methods:

  • Analysis of cell surface phenotype and transcriptional signature.
  • Investigation of Toll-like receptor (TLR) signaling pathways (TLR7/TLR9) in ABC formation.
  • Correlation of ABC prevalence with age and disease states.

Main Results:

  • ABCs depend on TLR7/TLR9 signals and Th1 cytokines for activation.
  • Increased prevalence of ABCs with age contributes to reduced B cell function.
  • ABCs are associated with specific autoantibody profiles in autoimmune diseases.

Conclusions:

  • Age-associated B cells play critical roles in immune responses, aging, and disease pathogenesis.
  • Targeting ABCs may offer therapeutic strategies for age-related immune decline and autoimmune conditions.
  • Further research into ABC physiology is warranted for translational applications.