Related Experiment Video
Updated: Dec 30, 2025
Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells
Published on: June 16, 2023
SNHG7: A novel vital oncogenic lncRNA in human cancers
Yong Zhou1, Bo Tian1, Jinming Tang2
1Department of the 2nd Department of Thoracic Surgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Abstract:
Long noncoding RNAs (lncRNAs) are a group of RNAs that lack protein-coding ability, with lengths greater than 200 nucleotides. Increasing evidence has indicated that they mediate multiple physiological and pathological processes by regulating gene expression at the epigenetic, transcriptional, post-transcriptional, and translational levels. The deregulation of lncRNAs was demonstrated to have tumor suppressive or oncogenic effects, and thus, these molecules play vital regulatory roles in tumor initiation and progression. Small nucleolar RNA hostgene 7 (SNHG7) is a lncRNA located on chromosome 9q34.3. Different studies have explored the potential role of SNHG7 in the development and progression of multiple human malignancies such as bladder, breast, colorectal, esophageal, gastric, and prostate cancer, as well as osteosarcoma, among others, and high expression predicts poor prognosis and poor survival for such patients. Moreover, this molecule can promote proliferation and metastasis, while inhibiting apoptosis in cancer cells. The present review highlights the latest insights into the expression, functional roles, and molecular mechanisms of SNHG7 in different human malignancies.
Insights
Small nucleolar RNA hostgene 7 (SNHG7), a long noncoding RNA, is frequently overexpressed in various cancers. Its dysregulation drives tumor progression, promoting proliferation and metastasis while inhibiting apoptosis, indicating poor patient prognosis.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long noncoding RNAs (lncRNAs) regulate gene expression at multiple levels and are implicated in various physiological and pathological processes.
- Deregulation of lncRNAs contributes to tumor initiation and progression, exhibiting either tumor-suppressive or oncogenic effects.
- Small nucleolar RNA hostgene 7 (SNHG7) is a lncRNA implicated in the development and progression of multiple human malignancies.
Purpose of the Study:
- To review the latest insights into the expression patterns of SNHG7 across different human cancers.
- To elucidate the functional roles and molecular mechanisms of SNHG7 in tumorigenesis.
- To highlight the prognostic significance of SNHG7 in various malignancies.
Main Methods:
- Literature review of studies investigating SNHG7 expression and function in human cancers.
- Analysis of data linking SNHG7 expression levels to patient prognosis and survival outcomes.
- Examination of molecular mechanisms by which SNHG7 influences cancer cell proliferation, metastasis, and apoptosis.
Main Results:
- SNHG7 is frequently overexpressed in diverse cancers including bladder, breast, colorectal, esophageal, gastric, and prostate cancer, as well as osteosarcoma.
- High SNHG7 expression is consistently associated with poor prognosis and reduced survival rates in cancer patients.
- SNHG7 promotes cancer cell proliferation and metastasis while concurrently inhibiting apoptosis.
Conclusions:
- SNHG7 plays a significant oncogenic role in the development and progression of multiple human malignancies.
- SNHG7 serves as a potential diagnostic and prognostic biomarker for various cancers.
- Targeting SNHG7 may represent a novel therapeutic strategy for cancer treatment.
More Related Videos
07:23Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
07:24Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
02:39lncRNA - Long Non-coding RNAs
02:23Abnormal Proliferation
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:33Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:03Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...