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Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
Published on: January 5, 2024
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How I Manage Cancer-Associated Thrombosis
Florian Moik1, Cihan Ay1,2
1Clinical Division of Haematology and Haemostaseology, Department of Internal Medicine I, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.
Hamostaseologie
|January 28, 2020
Summary
Managing cancer-associated venous thromboembolism (VTE) involves balancing recurrence and bleeding risks with direct oral anticoagulants (DOACs). This review guides VTE management in cancer patients, addressing challenges like incidental pulmonary embolism and thrombocytopenia.
Area of Science:
- Oncology
- Hematology
- Clinical Medicine
Background:
- Cancer patients frequently develop venous thromboembolism (VTE), increasing morbidity and mortality.
- Direct oral anticoagulants (DOACs) are increasingly used for VTE, but their role in cancer patients is evolving.
- Optimal anticoagulation in cancer-associated VTE requires balancing recurrence and bleeding risks.
Observation:
- Efficacy and safety of DOACs in cancer-associated VTE are now being evaluated in randomized controlled trials.
- Special clinical scenarios, including incidentally diagnosed pulmonary embolism and catheter-related thrombosis, pose management challenges.
- Concomitant thrombocytopenia can further complicate anticoagulation decisions in cancer patients.
Findings:
- Recent studies and guidelines inform the choice of anticoagulant agents for cancer-associated VTE.
- A case-based approach is presented to guide management in diverse clinical scenarios.
- Balancing bleeding and recurrence risks is central to selecting appropriate anticoagulation.
Implications:
- This review provides practical guidance for clinicians managing cancer patients with VTE.
- Understanding DOACs' role in this population is crucial for improving patient outcomes.
- Addressing complex scenarios like incidental PE and thrombocytopenia is essential for effective VTE care in oncology.
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