Related Experiment Video
Updated: Oct 9, 2026

Isolation of Soluble and Insoluble PrP Oligomers in the Normal Human Brain
Published on: October 3, 2012
Protein gradients in the cerebrospinal fluid and the calculation of intracerebral IgG synthesis
1Division of Neurology/Neurophysiology, Medical School, Hannover, F.R.G.
When six successive samples of 2.5 ml cerebrospinal fluid (CSF) were withdrawn from eight multiple sclerosis (MS) and 12 other neurological disease (OND) patients, the IgG index rose continuously between 2.9 and 24.0%, while both the Tourtellotte as well as the Reiber/Felgenhauer formulas were less affected.
When six successive samples of 2.5 ml cerebrospinal fluid (CSF) were withdrawn from eight multiple sclerosis (MS) and 12 other neurological disease (OND) patients, the IgG index rose continuously between 2.9 and 24.0%, while both the Tourtellotte as well as the Reiber/Felgenhauer formulas were less affected.
Related Concept Videos
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Cerebral Edema ll: Pathophysiology

