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Updated: Dec 29, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Chemical transformations of quaternary ammonium salts via C-N bond cleavage
1CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. zxwang@ustc.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. China.
Abstract:
Quaternary ammonium salts are readily prepared and show good reactivity in various organic transformations via C-N bond cleavage. In this review we summarize reactions of aryl, benzyl, allyl and propargyl quaternary ammonium salts including cross-coupling with organometallic reagents, as arylation or benzylation reagents in C-H functionalization, reductive deamination, reductive coupling, nucleophilic substitution, carboxylation with CO2, and carbonylation with CO to construct C-C, C-H and C-heteroatom bonds.
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