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Updated: Dec 29, 2025
05:58
Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
Published on: April 20, 2016
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Tissue-resident memory T cells in the skin.
Samar Khalil1, Tara Bardawil1, Mazen Kurban1,2
1Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.
Summary
Tissue-resident memory T (TRM) cells are crucial for immediate pathogen defense but can drive autoimmune skin diseases like psoriasis and vitiligo. Their role in melanoma suggests potential therapeutic targets.
Area of Science:
- Immunology
- Dermatology
- Cell Biology
Background:
- Tissue-resident memory T (TRM) cells are a specialized immune cell subset residing long-term in tissues.
- Characterized by CD8+ expression, CD103, and CD69, TRM cells offer immediate protection against pathogens.
- Dysregulated TRM cell activity is implicated in autoimmune and inflammatory conditions, particularly in the skin.
Purpose of the Study:
- To review current knowledge on TRM cell phenotype and function.
- To summarize TRM cell roles in various skin diseases, including psoriasis, vitiligo, and melanoma.
Main Methods:
- Comprehensive literature review.
- Analysis of existing data on TRM cell characteristics and functions.
- Synthesis of findings related to cutaneous conditions.
Main Results:
- In psoriasis, IL-17-producing TRM cells with shared antigen recognition may drive disease recurrence.
- In vitiligo, TRM cells produce cytotoxic molecules and collaborate with other T cells to sustain the disease.
- In melanoma, increased TRM cell infiltration correlates with better survival in patients on immune checkpoint inhibitors.
Conclusions:
- TRM cells play multifaceted roles in skin immunity, from protective responses to driving inflammatory diseases.
- Understanding TRM cell behavior is key to developing targeted therapies for autoimmune skin conditions and optimizing cancer immunotherapy.
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