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Updated: Dec 29, 2025

In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology
Published on: September 29, 2023
Biotinylated photoactive Pt(iv) anticancer complexes
Huayun Shi1, Cinzia Imberti, Huaiyi Huang
1Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. p.j.sadler@warwick.ac.uk.
Abstract:
Novel biotinylated diazido-Pt(iv) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all-trans-[Pt(py)2(N3)2(biotin)(OH)] (2a) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with 2a.
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