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Factors affecting mortality in children with dilated cardiomyopathy
Muhammed Nurullah Sabaz1, Alper Akın2, Meki Bilici2
1Department of Pediatrics, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
The Turkish Journal of Pediatrics
|January 29, 2020
Summary
Pediatric dilated cardiomyopathy (DCMP) has high mortality. Sinus tachycardia, longer corrected QT (QTc) intervals, and ECG ST-T wave changes at diagnosis predict mortality in children with DCMP.
Area of Science:
- Pediatrics
- Cardiology
- Medical Research
Background:
- Dilated cardiomyopathy (DCMP) is a serious pediatric heart condition with significant mortality rates.
- The etiology of pediatric DCMP is often linked to genetic and infectious factors.
Purpose of the Study:
- To investigate the causes of DCMP in children.
- To identify parameters that predict mortality in pediatric patients diagnosed with DCMP.
Main Methods:
- Retrospective analysis of 37 pediatric patients diagnosed with DCMP between January 2012 and October 2016.
- Comparison of clinical, laboratory, echocardiography, and electrocardiography (ECG) findings between surviving and non-surviving patients.
Main Results:
- A majority of patients (67.6%) were diagnosed before 12 months of age.
- Non-surviving patients showed a higher incidence of sinus tachycardia (83.3% vs. 29%), longer corrected QT (QTc) intervals (p=0.007), and more frequent ST-T wave changes on ECG (80% vs. 17.8%, p=0.012).
Conclusions:
- Early diagnosis (under one year) is common in pediatric DCMP.
- Sinus tachycardia, prolonged QTc, and ECG ST-T wave abnormalities are significant predictors of mortality in children with dilated cardiomyopathy.
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