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Updated: Dec 29, 2025

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
Published on: July 20, 2016
An oral drug for chronic lymphocytic leukemia
1Amber Koehler practices in this Division of Hematology at the Mayo Clinic in Rochester, Minn., and is an assistant professor of medicine in the Mayo Clinic College of Medicine. The author has disclosed no potential conflicts of interest, financial or otherwise.
Abstract:
Ibrutinib is a new first-line drug for treating chronic lymphocytic leukemia (CLL), and could change frontline treatment of CLL from traditional IV chemotherapy to oral targeted therapy. Lymphocytosis often worsens with initiation of ibrutinib, but typically resolves over 6 to 18 months. Though patients generally tolerate ibrutinib well, the drug can cause adverse reactions including hypertension, atrial fibrillation, bleeding, and infections such as fungal pneumonia.
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