Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

573
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
573
Viral Structure00:56

Viral Structure

73.5K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
73.5K
What are Viruses?00:50

What are Viruses?

127.2K
Overview
127.2K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

624
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
624
Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

3.3K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DUSP1 is a Key Driver of Disease Persistence and Potential Therapeutic Target in Hairy Cell Leukemia.

Blood advances·2026
Same author

Evaluating Molecular Docking Programs for RNA-Targeted Ligand Screening: Influence of Binding Modes and Ligand Types.

Journal of chemical information and modeling·2026
Same author

Dengue Virus Capsid Protein Interaction With Nucleic Acids.

BioFactors (Oxford, England)·2026
Same author

Conservation of Bacterial Lipopolysaccharide Binding by SARS-CoV-2 Spike across Major Viral Variants.

Computational and structural biotechnology journal·2026
Same author

Smooth-to-rough morphotype switching, a mechanism of phage resistance in <i><i>Mycobacterium</i> abscessus</i>.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Multiscale Simulations and Cryo-Electron Microscopy Reveal the Transition Pathway of Dengue Virus-like Particle Nanoassembly.

ACS nano·2026

Related Experiment Video

Updated: Dec 29, 2025

Open-source Single-particle Analysis for Super-resolution Microscopy with VirusMapper
07:38

Open-source Single-particle Analysis for Super-resolution Microscopy with VirusMapper

Published on: April 9, 2017

10.4K

Multiscale modelling and simulation of viruses.

Jan K Marzinek1, Roland G Huber1, Peter J Bond2

  • 1Bioinformatics Institute (BII), Agency for Science, Technology and Research (A⁎STAR), 30 Biopolis Street, Matrix #07-01, 138671 Singapore, Singapore.

Current Opinion in Structural Biology
|January 29, 2020
PubMed
Summary
This summary is machine-generated.

Recent advances in computational modeling provide new insights into viral structure, dynamics, and host interactions. This understanding is crucial for developing effective antiviral therapies and combating viral diseases.

More Related Videos

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
10:11

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes

Published on: September 27, 2014

36.9K
Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice
08:31

Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice

Published on: July 20, 2022

3.6K

Related Experiment Videos

Last Updated: Dec 29, 2025

Open-source Single-particle Analysis for Super-resolution Microscopy with VirusMapper
07:38

Open-source Single-particle Analysis for Super-resolution Microscopy with VirusMapper

Published on: April 9, 2017

10.4K
Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
10:11

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes

Published on: September 27, 2014

36.9K
Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice
08:31

Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice

Published on: July 20, 2022

3.6K

Area of Science:

  • Structural biology
  • Computational modeling
  • Virology

Background:

  • Viruses present significant challenges in prevention and treatment.
  • Understanding viral structure and dynamics is essential for developing new therapies.

Purpose of the Study:

  • To survey recent studies on computational models of viruses.
  • To elucidate mechanisms of viral function and host interactions.

Main Methods:

  • Structural biology techniques
  • Integrative modeling approaches
  • Simulation methods

Main Results:

  • Unprecedented insights into viral structure and dynamics.
  • Development of computational models for viruses.
  • Elucidation of viral interactions with host factors.

Conclusions:

  • Enhanced mechanistic understanding of viral infection is vital.
  • Accurate models of viral interactions are essential for novel therapeutic strategies.