Synthesis of Biologically Active Molecules through Multicomponent Reactions

Area of Science:

• Organic Chemistry
• Medicinal Chemistry
• Drug Discovery

Background:

• Multicomponent reactions (MCRs) have emerged as powerful synthetic tools since 2002.
• These reactions enable the rapid assembly of complex organic molecules from multiple starting materials in a single step.

Purpose of the Study:

• To review the literature on MCRs focusing on compounds with demonstrated biological activity.
• To highlight the significance of MCRs in accelerating the synthesis of potential drug candidates.

Main Methods:

• Systematic literature search for studies published since 2002 involving MCRs.
• Selection of papers reporting biologically active compounds synthesized via MCRs.
• Organization of data into schemes and tables for clarity and comparison.

Main Results:

• A vast number of organic molecules have been synthesized using MCRs.
• Many MCR-derived compounds exhibit significant biological activities or have undergone biological screening.
• The review consolidates diverse synthetic approaches and biological evaluations.

Conclusions:

• MCRs are indispensable for efficient synthesis of biologically relevant molecules.
• The strategic application of MCRs accelerates the discovery of novel bioactive compounds.
• This review provides a valuable resource for researchers in organic synthesis and medicinal chemistry.