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The Effect of Pregabalin on the Prevention of Succinylcholine-Induced Fasciculation and Myalgia
Shahryar Sane1, Mir Moussa Aghdashi1, Behzad Kazemi Haki1
1Department of Anesthesiology, Urmia Imam Khomeini Hospital, Urmia University of Medical Science, Urmia, Iran.
Purpose:
This study evaluates the effect of pregabalin on fasciculation and myalgia after using succinylcholine.
Design:
This randomized double-blind prospective study was conducted among 100 patients aged 20 to 60 years old.
Methods:
Pregabalin (300 mg) and placebo (in capsule form) were placed in similar containers. The results were analyzed by SPSS 23 software, and statistical analysis consisted of χ2 test and t test, and a P value less than .05 was considered significant.
Findings:
The mean pain score in the group receiving pregabalin was lower than the placebo group. According to the χ2 test, there was a significant difference between the two groups in the frequency of fasciculation (P = .003). Mean fasciculation severity in the pregabalin group was lower than placebo group. According to t test, there was a significant difference in the mean fasciculation severity between the two groups (P = .002).
Conclusions:
This study showed that 300 mg of pregabalin was effective in reducing postoperative fasciculation and myalgia in patients treated with succinylcholine.
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