Related Experiment Video
Updated: Dec 29, 2025
08:07
Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells
Published on: January 7, 2019
11.4K
Emerging Roles for Lymphatics in Chronic Liver Disease
Matthew A Burchill1, Alyssa R Goldberg1,2, Beth A Jirón Tamburini1,3
1Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, CO, United States.
Frontiers in Physiology
|January 30, 2020
Summary
Chronic liver disease (CLD) involves liver inflammation and cholesterol buildup. Liver lymphatics, though overlooked, expand in CLD, suggesting a role in disease progression and potential therapeutic targets.
Area of Science:
- Hepatology
- Lymphatic Biology
- Immunology
Background:
- Chronic liver disease (CLD) is a major global health issue with rising incidence.
- CLD is characterized by hepatic steatosis, inflammation, and cholesterol accumulation.
- Liver lymphatics' role in hepatic function and CLD pathogenesis is understudied.
Purpose of the Study:
- To review current knowledge of liver lymphatics in health and disease.
- To explore the impact of obesity and hypercholesterolemia on liver lymphatics.
- To investigate changes in liver lymphatic endothelial cells (LECs) during CLD.
Main Methods:
- Literature review of liver lymphatics in health and disease.
- Analysis of studies on obesity and hypercholesterolemia effects on lymphatics in other organs.
- Examination of transcriptional changes in liver LECs during CLD.
Main Results:
- Liver lymphatics expand in number and size across various CLD etiologies.
- Lymphatic endothelial cells (LECs) upregulate proliferation genes in CLD.
- Disease-specific inflammatory mediators induce distinct transcriptional changes in liver LECs.
Conclusions:
- Liver lymphatic expansion occurs in CLD, indicating potential functional alterations.
- Understanding LECs' transcriptional changes is crucial for elucidating CLD mechanisms.
- Further research is needed to determine if these lymphatic changes induce dysfunction and impact liver function.
Keywords:
ascitescholesterolchronic liver diseasefatty acidsliver lymphaticslymphatic endothelial cellobesityportal hypertensionMore Related Videos
Related Concept Videos
01:16Lymphatic Vessels and Lymph Transport
21.7K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
21.7K
01:28Functions of the Lymphatic and Immune System
6.2K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
6.2K
01:15Development of the Lymphatic System
1.8K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
1.8K
01:28Esophageal Varices-II: Clinical Features and Management
315
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
315
01:26Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
170
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
170
01:24Chronic Pancreatitis I: Introduction
621
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
621