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Updated: Dec 29, 2025

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
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In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells

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The Role of Tumor-Derived Vesicles in the Regulation of Antitumor Immunity

V M Ukrainskaya1, Y P Rubtsov1, V D Knorre1

  • 1M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, 117997 Russia.

Acta Naturae
|January 30, 2020
PubMed

Insights

Tumor-derived vesicles (TDVs) mediate communication between cancer and immune cells, often suppressing anti-tumor immunity. Further research into TDV heterogeneity and function could lead to new cancer therapies.

Area of Science:

  • Immunology
  • Cancer Biology
  • Cell Biology

Background:

  • Tumor-derived vesicles (TDVs) are crucial mediators of intercellular communication in the tumor microenvironment.
  • TDVs play a significant role in modulating immune responses, particularly T cell activity.
  • Recent advancements have deepened our understanding of vesicle-mediated communication over the past 15 years.

Purpose of the Study:

  • To provide a comprehensive review of the current knowledge on TDVs' function in tumor-immune cell crosstalk.
  • To elucidate the structure, biogenesis, and major functions of TDVs.
  • To focus on the mechanisms by which TDVs suppress or activate CD4+ and CD8+ T cells.

Main Methods:

  • Literature review and synthesis of existing research on TDVs.
  • Analysis of studies characterizing TDV structure, biogenesis, and function.
  • Focus on research detailing TDV interactions with T cells (CD4+ and CD8+).

Main Results:

  • TDVs are key players in suppressing anti-tumor immunity.
  • TDVs can either suppress or activate CD4+ and CD8+ T cells through various mechanisms.
  • Significant progress has been made in understanding TDV-mediated intercellular communication.

Conclusions:

  • Despite progress, knowledge gaps remain regarding TDV heterogeneity, isolation, uptake, and mRNA roles.
  • TDVs are critical regulators of the immune response within the tumor microenvironment.
  • Emerging strategies targeting TDV inhibition in tumors show promise for novel cancer therapies.
Keywords:
CD4+/CD8+ T cellsexosomesimmune responsetumor microenvironmentvesicles

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