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Why not add some SPARKL to your life (and death)!?
Jesse D Gelles1,2, Jerry Edward Chipuk1,2,3,4,5
1Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Molecular & Cellular Oncology
|January 30, 2020
Abstract:
Quantifying cytostatic and cytotoxic outcomes of cells responding to perturbagens is an essential component of mechanism-based studies and pharmacological screening approaches. We recently described an easy and versatile method for single-cell and population-level analyses using real-time kinetic labeling (SPARKL). This technology enables zero-handling, non-disruptive protocols for integrating proliferation profiles with cell death mechanisms, along with advanced mathematics for robust analyses.