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Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

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Is bronchiectasis really a disease?

Michal Shteinberg^1,2, Patrick A Flume³, James D Chalmers⁴

¹Pulmonology Institute and CF Center, Carmel Medical Center, Haifa, Israel michalsh@technion.ac.il.

European Respiratory Review : an Official Journal of the European Respiratory Society

|January 31, 2020

Summary

This summary is machine-generated.

Bronchiectasis is a complex lung disease with shared features and "treatable traits" with other airway conditions. Its heterogeneity necessitates a targeted therapeutic approach rather than a restrictive definition.

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Area of Science:

Pulmonology
Respiratory Medicine
Disease Pathogenesis

Background:

Defining diseases requires distinct, common signs and symptoms.
Bronchiectasis presents with anatomical changes, airway inflammation, and infection.
Bronchiectasis is heterogeneous with shared symptoms and multiple causes.

Purpose of the Study:

To address the definition and heterogeneity of bronchiectasis.
To evaluate the concept of bronchiectasis as a "treatable trait".
To advocate for a targeted therapeutic strategy for bronchiectasis.

Main Methods:

Review of existing literature on bronchiectasis definition and pathogenesis.
Analysis of clinical and laboratory features across bronchiectasis phenotypes.
Consideration of therapeutic intervention responses in clinical trials.

Main Results:

Bronchiectasis shares pathophysiological features and "treatable traits" with other airway diseases.
Significant heterogeneity exists in bronchiectasis pathogenesis and clinical presentation.
Therapeutic responses in bronchiectasis are not uniform across patients.

Conclusions:

Bronchiectasis should be defined as a distinct disease entity.
Its heterogeneity stems from shared pathophysiological features and "treatable traits".
A targeted, individualized approach to therapy is recommended for bronchiectasis.