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Whole-body PET/MRI of Pediatric Patients: The Details That Matter
Published on: December 19, 2017
The current status and further prospects for lung magnetic resonance imaging in pediatric radiology
Franz Wolfgang Hirsch1, Ina Sorge2, Jens Vogel-Claussen3,4
1Department of Pediatric Radiology, University of Leipzig, Liebigstraße 20a, 04103, Leipzig, Germany. fw.hirsch@medizin.uni-leipzig.de.
Abstract:
Lung MRI makes it possible to replace up to 90% of CT examinations with radiation-free magnetic resonance diagnostics of the lungs without suffering any diagnostic loss. The individual radiation exposure can thus be relevantly reduced. This applies in particular to children who repeatedly require sectional imaging of the lung, e.g., in tumor surveillance or in chronic lung diseases such as cystic fibrosis. In this paper we discuss various factors that favor the establishment of lung MRI in the clinical setting. Among the many sequences proposed for lung imaging, respiration-triggered T2-W turbo spin-echo (TSE) sequences have been established as a good standard for children. Additional sequences are mostly dispensable. The most important pulmonary findings are demonstrated here in the form of a detailed pictorial essay. T1-weighted gradient echo sequences with ultrashort echo time are a new option. These sequences anticipate signal loss in the lung and deliver CT-like images with high spatial resolution. When using self-gated T1-W ultrashort echo time 3-D sequences that acquire iso-voxel geometry in the sub-millimeter range, secondary reconstructions are possible.
Insights
Radiation-free lung MRI can replace most CT scans, significantly reducing radiation exposure, especially for children needing frequent lung imaging for conditions like cystic fibrosis or tumors.
Area of Science:
- Radiology
- Medical Imaging
- Pulmonology
Background:
- Computed tomography (CT) involves significant radiation exposure, a concern for all patients, particularly children requiring repeated lung imaging.
- Lung imaging is crucial for diagnosing and monitoring various pulmonary conditions, including tumors and chronic diseases like cystic fibrosis.
Purpose of the Study:
- To evaluate the potential of lung Magnetic Resonance Imaging (MRI) to replace conventional CT examinations.
- To discuss factors facilitating the clinical adoption of lung MRI.
- To present key pulmonary findings using MRI through a pictorial essay.
Main Methods:
- Review of established and novel MRI sequences for lung imaging.
- Focus on respiration-triggered T2-weighted turbo spin-echo (TSE) sequences as a standard for pediatric lung imaging.
- Exploration of T1-weighted gradient echo sequences with ultrashort echo time (T1-W UTE) for high-resolution imaging.
Main Results:
- Lung MRI can substitute up to 90% of CT examinations without diagnostic compromise.
- Radiation-free lung MRI significantly reduces individual radiation exposure, crucial for pediatric patients.
- T1-W UTE sequences offer CT-like image quality with high spatial resolution, enabling detailed secondary reconstructions.
Conclusions:
- Lung MRI is a viable, radiation-free alternative to CT for lung diagnostics, especially in pediatric populations.
- Respiration-triggered T2-W TSE sequences are a reliable standard for pediatric lung MRI.
- Advanced sequences like T1-W UTE provide high-resolution imaging, expanding MRI's utility in pulmonary diagnostics.
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