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Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
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Interplay between inflammation and cancer
1Department of Genetics, Barkatullah University, Bhopal, Madhya Pradesh, India.
Advances in Protein Chemistry and Structural Biology
|January 31, 2020
Summary
The link between chronic inflammation and cancer development is well-established. Understanding shared pathways can help fight both inflammation and cancer effectively.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- The connection between inflammation and cancer was first identified in the 19th century.
- The tumor microenvironment includes inflammatory cells crucial for cancer progression.
- Chronic inflammation, from infections or environmental factors, can lead to carcinogenesis.
Purpose of the Study:
- To explore the intricate relationship between inflammation and cancer.
- To highlight the role of the inflammatory microenvironment in tumor development.
- To investigate common pathways for therapeutic intervention.
Main Methods:
- Review of historical and contemporary research on inflammation and cancer.
- Analysis of the cellular components within the tumor microenvironment.
- Examination of cytokine-mediated apoptotic pathways (e.g., TRAIL).
Main Results:
- Chronic inflammation is a significant risk factor for cancer development.
- Tumor microenvironments are rich in diverse inflammatory cells.
- Cytokines like TRAIL initiate apoptosis via death receptors, influencing cancer progression.
- Anti-inflammatory drugs show potential in cancer treatment, suggesting shared mechanisms.
Conclusions:
- Inflammation and cancer share common underlying pathways.
- Targeting these shared pathways could offer novel therapeutic strategies for both conditions.
- Further research into these common mechanisms is vital for developing effective treatments.
Keywords:
CancerDeath receptorsInflammationInterleukinsTRAILTumor associated macrophages (TAMs)Tumor associated neutrophils (TANs)Tumor microenvironmentMore Related Videos
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