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Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Published on: June 7, 2024

Interplay between inflammation and cancer.

Rekha Khandia¹, Ashok Munjal¹

¹Department of Genetics, Barkatullah University, Bhopal, Madhya Pradesh, India.

Advances in Protein Chemistry and Structural Biology

|January 31, 2020

Summary

The link between chronic inflammation and cancer development is well-established. Understanding shared pathways can help fight both inflammation and cancer effectively.

Keywords:

Cancer Death receptors Inflammation Interleukins TRAIL Tumor associated macrophages (TAMs)Tumor associated neutrophils (TANs)Tumor microenvironment

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Area of Science:

Oncology
Immunology
Pathology

Background:

The connection between inflammation and cancer was first identified in the 19th century.
The tumor microenvironment includes inflammatory cells crucial for cancer progression.
Chronic inflammation, from infections or environmental factors, can lead to carcinogenesis.

Purpose of the Study:

To explore the intricate relationship between inflammation and cancer.
To highlight the role of the inflammatory microenvironment in tumor development.
To investigate common pathways for therapeutic intervention.

Main Methods:

Review of historical and contemporary research on inflammation and cancer.
Analysis of the cellular components within the tumor microenvironment.
Examination of cytokine-mediated apoptotic pathways (e.g., TRAIL).

Main Results:

Chronic inflammation is a significant risk factor for cancer development.
Tumor microenvironments are rich in diverse inflammatory cells.
Cytokines like TRAIL initiate apoptosis via death receptors, influencing cancer progression.
Anti-inflammatory drugs show potential in cancer treatment, suggesting shared mechanisms.

Conclusions:

Inflammation and cancer share common underlying pathways.
Targeting these shared pathways could offer novel therapeutic strategies for both conditions.
Further research into these common mechanisms is vital for developing effective treatments.