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Updated: Dec 29, 2025

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
Published on: November 29, 2019
Multiple myeloma with clivus involvement, neurological symptoms, and 45 g/L proteinorachia
Yannick Chantran1,2, Jean-Rémi Lavillegrand3, Bertrand Lefrere1
1Immunology Department Hôpital Saint-Antoine, AP-HP Paris France.
Abstract:
The mechanical obstruction of cerebrospinal fluid (CSF) flow can lead to very high hyperproteinorachia. In myeloma, tumoral clivus obstruction can cause such high proteinorachia, associated with paraprotein detection in the CSF in absence of intrathecal synthesis.
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