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Updated: Dec 29, 2025
12:06
Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
Published on: May 12, 2011
21.2K
Herpetic optic perineuritis presenting as classic abducens nerve palsy
Muhammad Abbas Abid1, Mustafa Mughal2, Peter Capelli3
1Department of Otolaryngology - Head & Neck Surgery Johns Hopkins University School of Medicine Baltimore MD USA.
Clinical Case Reports
|January 31, 2020
Summary
Optic perineuritis, a rare herpes zoster ophthalmicus (HZO) complication, can be detected early. Recognizing relative afferent pupillary defect (RAPD) aids timely management of this sight-threatening condition.
Area of Science:
- Ophthalmology
- Neurology
- Infectious Diseases
Background:
- Optic perineuritis is an uncommon but serious complication of herpes zoster ophthalmicus (HZO).
- Early detection of neurological involvement is crucial for preventing vision loss.
Purpose of the Study:
- To highlight optic perineuritis as a rare manifestation of HZO.
- To emphasize the significance of relative afferent pupillary defect (RAPD) as an early indicator of nerve involvement.
Main Methods:
- Case review and clinical examination findings.
- Analysis of diagnostic criteria for optic perineuritis in HZO patients.
- Correlation of clinical signs with neurological sequelae.
Main Results:
- Relative afferent pupillary defect (RAPD) is a key early sign of impending optic nerve involvement in HZO.
- Clinical examination is vital for identifying this rare, metachronous manifestation.
Conclusions:
- Prompt recognition of RAPD in HZO cases can lead to early diagnosis of optic perineuritis.
- Timely management of optic perineuritis is essential to preserve vision in patients with HZO.
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