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Protein-based nanoplatforms for tumor imaging and therapy
Kaicheng Liang1,2, Hangrong Chen1
1State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|January 31, 2020
Summary
Protein-based nanoplatforms show promise for cancer diagnosis and therapy due to their biocompatibility and functional groups. This review highlights advancements in using proteins like albumin and ferritin as nanocarriers for tumor imaging and treatment.
Area of Science:
- * Biology-Inspired Nanomaterials
- * Nanomedicine for Oncologic Disease
Background:
- * Cancer remains a leading global cause of mortality.
- * Nanoplatforms offer promising strategies for cancer diagnosis and treatment.
- * Protein nanocarriers are advantageous due to biocompatibility, functional groups, and biological activity.
Purpose of the Study:
- * To review recent advancements in protein-based nanoplatforms for cancer applications.
- * To discuss common protein nanocarriers, their properties, and applications.
- * To summarize future prospects and challenges in the field.
Main Methods:
- * Comprehensive literature review of protein-based nanoplatforms.
- * Analysis of physiochemical properties and applications of common protein nanocarriers (e.g., human/bovine serum albumin, ferritin, human transferrin).
- * Inclusion of other relevant protein types and their roles.
Main Results:
- * Protein-based nanoplatforms are effective for tumor imaging and therapy.
- * Specific proteins like albumin, ferritin, and transferrin demonstrate significant potential.
- * Diverse applications in nanomedicine for oncologic disease are emerging.
Conclusions:
- * Protein-based nanoplatforms represent a significant area of advancement in cancer nanomedicine.
- * Further research is needed to overcome challenges and fully realize their therapeutic potential.
- * Continued development holds promise for improved cancer diagnosis and treatment strategies.
