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Updated: Dec 29, 2025
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Periodontal disease might be a risk factor for graft versus host disease. A systematic review
Alexandru Mester1, Alexandra Iulia Irimie2, Alina Tanase3
1Department of Oral Health, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania.
Purpose:
The aim of this systematic review was to determine a potential association between periodontal disease and graft versus host disease (GVHD).
Design:
PubMed, Scopus and Web of Science databases were searched to identify all relevant articles. The eligibility criteria were prospective, retrospective, cross-sectional, cohort, case-control studies and interventional studies that assessed periodontal parameters in GVHD adults' patients.
Results:
Seven studies, published between 2000 and 2018, were eligible. The aggravation of periodontal tissues is due to inadequate oral hygiene, dental plaque, decays, gum recession, retained roots, tooth loss, periodontally infected teeth. Several studies have indicated that periodontitis treatment performed before transplantation showed the reduction of gingival inflammation and maintenance of periodontal health.
Conclusions:
Periodontitis might be a risk factor for GVHD. However, due to the limited number of studies included in the review and their heterogeneity, more data are needed to sustain the correlation between periodontitis and GVHD.
