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Updated: Dec 29, 2025

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
Published on: December 15, 2017
Minimizing membrane bioreactor environmental footprint by multiple objective optimization
Giorgio Mannina1, Bing-Jie Ni2, Taise Ferreira Rebouças3
1Engineering Department, Palermo University, Viale delle Scienze, Ed.8, 90128 Palermo, Italy; School of Environmental and Municipal Engineering, Tianjin Chengjian University, 26 Jinjing Road, Xiqing District, Tianjin 300384, China.
Abstract:
This paper presents a modelling study aimed at minimizing the environmental foot print of a membrane bioreactor (MBR) for wastewater treatment. Specifically, an integrated model for MBR was employed in view of the management optimization of an MBR biological nutrient removal (BNR) pilot plant in terms of operational costs and direct greenhouse gases emissions. The influence of the operational parameters (OPs) on performance indicators (PIs) was investigated by adopting the Extended-FAST sensitivity analysis method. Further, a multi-objective analysis was performed by applying the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS). The results show-up that the sludge retention time is the OP mostly affecting all the investigated PIs. By applying the set of optimal OPs, there was a reduction of 48% and 10% of the operational costs and direct emissions, respectively.
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